Does educational attainment shape reactions to genetic risk for Alzheimer's disease? Results from a national survey experiment

- How individuals manage specific health risks may yield educational health inequality.
- Whether education shapes reactions to Alzheimer's Disease (AD) risk remains unclear.
- Using vignettes, we assess participant reactions to varying levels of AD genetic risk.
- Educational differences in AD risk reactions often are substantial or vary by age.

While higher education is associated with healthy lifestyles and health literacy, it remains unclear whether education shapes reactions to varying levels of genetic risk for Alzheimer's disease (AD). In this study, participants (N = 701) in the National Genetic Risk Survey Experiment (NGRISE) received a hypothetical genetic risk assessment for AD (ranging from 20 to 80% lifetime risk) and then completed items on their cognitive (perceived threat to health), emotional (general negative affect), and anticipated behavioral (seek information, improve health behaviors, engage in public or private civic action) reactions to this risk. Individuals with a college education showed reactions to increasing genetic risk approximately twice or several times as strong relative to those of individuals with lower (high school, HS) education. In fact, behavioral reactions do not significantly increase with AD risk among those with HS education. Some educational differences in risk response widen at older ages.