کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5503214 | 1535087 | 2017 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prevalence of Peripheral Neuropathy and associated factors in HIV-infected patients
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کلمات کلیدی
mini-mental status examCD4 lymphocyte countIENFDGCsHAARTMMSEDSM-5CIDPTobacco use - استفاده از تنباکوAIDS - ایدزIntraepidermal nerve fiber density - تراکم فیبر داخل عضلانیhighly active antiretroviral therapy - درمان ضد رتروویروسی بسیار فعالImmune reconstitution inflammatory syndrome - سندرم التهابی بازسازی ایمنbody mass index - شاخص توده بدنBMI - شاخص توده بدنیPrevalence - شیوعIris - عنبیهChronic inflammatory demyelinating polyradiculoneuropathy - مزمن مزمن polyradiculoneuropathy demyelinating التهابیGlasgow coma scale - مقیاس کما گلاسکوHepatitis C virus - هپاتیت سیHCV - هپاتیت سیHIV - ویروس نقص ایمنی انسانی peripheral neuropathy - پلینوریت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The progress on HIV infection treatment has allowed a longer survival for HIV-infected patients. However, chronic comorbidities are emerging. Peripheral Neuropathy (PN) represents one of the most prevalent neurologic disorders among these patients, and comprehensive studies may contribute to a reduction in the morbidity of this condition. This is a cross-sectional analytic study conducted in a tertiary referral hospital in southern Brazil. This study investigates the prevalence of PN among HIV-infected patients and associated demographic, clinical and laboratory variables. A number of 150 HIV-infected patients admitted between January and May 2016 were interviewed, submitted to physical and neurological examination, and data from their medical records were obtained. The prevalence of PN was 31.3%. It was increased among older patients (p = 0.02), patients with higher CD4 lymphocytes levels (p = 0.02), and smokers (OR = 3.4; 95% CI 1.6-6.9; p < 0.01). The research identified a high prevalence of PN in HIV-infected patients. Older age and higher CD4 levels have been associated with PN. To the best of our knowledge, this was one of the first studies reporting an association between tobacco use and PN among HIV-infected patients. Further studies are necessary to elucidate the pathological mechanisms linking PN and tobacco.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 375, 15 April 2017, Pages 316-320
Journal: Journal of the Neurological Sciences - Volume 375, 15 April 2017, Pages 316-320
نویسندگان
Maria Luiza Areal Corrêa de Sá e Benevides, Sérgio Beduschi Filho, Rodrigo Debona, Eduardo Novaes Costa Bergamaschi, Jean Costa Nunes,