کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5503675 | 1535590 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD34+ cell count predicts long lasting life in the oldest old
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Circulating progenitor cells (CPCs) represent a pool of cells capable of differentiating into mature cells of different organs and systems, promoting tissue maintenance and repair. Among CPCs, CD34Â +Â cells (CD34Â +Â CPCs) seem to predict outcome in CV disease, also in elderly people. A decline in CD34Â +Â CPCs was reported with advancing age. Moreover, aging is associated with a state of chronic inflammation, influencing life expectancy. Our purpose was to investigate a 10-year predictive ability of CD34Â +Â CPCs, inflammatory marker levels, classic CV risk factors (CVRFs), and Framingham Risk Score (FRS) in a population of healthy, self-sufficient octogenarians. We found that baseline CD34Â +Â CPCs was strongly associated with mortality, showing a significant difference in CD34Â +Â CPC numbers between deceased and living patients. Moreover, by dividing our patients into tertiles based on age reached, this difference was more remarkable the higher the age reached. Regressive analyses suggested that the chances of reaching an older age depend on higher CD34Â +Â CPCs at baseline and are not significantly affected by inflammatory markers levels, FRS, CVFRs, or HDL-C levels. We found that higher CD34Â +Â CPCs predict longer life also in the oldest old, providing additional insights on the predictive role of CD34Â +Â CPCs in subjects aged 80 years or more.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 164, June 2017, Pages 139-145
Journal: Mechanisms of Ageing and Development - Volume 164, June 2017, Pages 139-145
نویسندگان
Giuseppe Mandraffino, Caterina Oriana Aragona, Giorgio Basile, Valentina Cairo, Federica Mamone, Carmela Morace, Angela D'Ascola, Angela Alibrandi, Alberto Lo Gullo, Saverio Loddo, Antonino Saitta, Egidio Imbalzano,