کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5504253 1535868 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking
چکیده انگلیسی

Rab11 and phosphoinositides are signal transducers able to direct the delivery of membrane components to the cell surface. Rab11 is a small GTPase that, by cycling from an active to an inactive state, controls key events of vesicular transport, while phosphoinositides are major determinants of membrane identity, modulating compartmentalized small GTPase function. By sharing common effectors, these two signal transducers synergistically direct vesicular traffic to specific intracellular membranes. This review focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Biological Regulation - Volume 63, January 2017, Pages 132-139
نویسندگان
, ,