کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5504354 1536279 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A singular mutation in the hemagglutinin of the 1918 pandemic virus
ترجمه فارسی عنوان
جهش اختصاصی در هموگلوتینین ویروس پاندمی 1918
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The influenza pandemic of 1918-1919 killed at least 50 million people. The reasons why this pandemic was so deadly remain largely unknown [9]. However, It has been shown that the 1918 viral hemagglutinin allows to reproduce the hallmarks of the illness observed during the original pandemic [11]. Thanks to the wealth of hemagglutinin sequences accumulated over the last decades, amino-acid substitutions that are found in the 1918-1919 sequences but rare otherwise can be identified with high confidence. Noteworthy, Gly 188, which is located within a key motif of the receptor binding site, has never been observed again in sequences of human viruses of subtype H1. Monitoring this singular mutation in viral sequences may help prevent another dramatic pandemic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volumes 625–626, 1 July 2017, Pages 13-16
نویسندگان
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