کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5507521 1400332 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mapping out the intricate relationship of the HIV envelope protein and the membrane environment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Mapping out the intricate relationship of the HIV envelope protein and the membrane environment
چکیده انگلیسی
The HIV gp160 envelope fusion protein is situated in the viral membrane and mediates virus entry into its host cell. Increasing evidence suggests that virtually all parts of the HIV envelope are structurally and functionally dependent on membranes. Protein-lipid interactions and membrane properties influence the dynamics of a manifold of gp160 biological activities such as membrane fusion, immune suppression and gp160 incorporation into virions during HIV budding and assembly. In the following we will summarize our current understanding of this interdependence between membrane interaction, structural conformation and functionality of the different gp160 domains. This article is part of a Special Issue entitled: Lipid order/lipid defects and lipid-control of protein activity edited by Dirk Schneider.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1859, Issue 4, April 2017, Pages 550-560
نویسندگان
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