کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5507759 | 1400347 | 2017 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Eicosapentaenoic acid modulates the synergistic action of CREB1 and ID/E2A family members in the rat pup brain and mouse embryonic stem cells
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کلمات کلیدی
Retinoid X receptorinhibitor of DNA bindingLIFmESCRXRGPR40PLPCREBPUFAsbHLHPPAREPACa2 + - Ca2 +Proteolipid protein - Proteolipid پروتئینBasic-helix-loop-helix - اسلحه پایه سیلیکونی حلقه ایEicosapentaenoic acid - اسید ایکوزاپنتانوئیکPolyunsaturated fatty acids - اسید چرب اشباع نشدهRetinoic acid - رتینوئیک اسیدEmbryonic stem cell - سلول های بنیادی جنینیMouse embryonic stem cells - سلول های بنیادی جنینی موشLipid signaling - سیگنالینگ لیپیدleukemia inhibitory factor - عامل مهارکننده لوکمیMultiprotein complex - مجتمع چندتاییcyclic AMP response element-binding protein - پروتئین اتصال دهنده عنصر Response Cyclic AMPperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an “EPA-cyclic AMP response element-binding protein (CREB)” signaling pathway. The current study reveals that EPA modulates the exquisite interplay of interaction of CREB1 with the inhibitor of DNA binding (ID) and E2A family members, thereby delivering mechanistic insights into specific neural differentiation program. In this scenario, our work provides evidence for the capability of CREB1 to sequester ID:E2A family members in brain tissues and neural differentiating mouse embryonic stem cells (mESCs) through formation of a [CREB1]2:ID2:E47 tetrameric complex.In essence, the molecular function of CREB1 is to dynamically regulate the location-specific assembly or disassembly of basic-helix-loop-helix (bHLH):HLH protein complexes to mediate the activation of neural/glial target genes. Together, these findings support the one-to-many binding mechanism of CREB1 and indicate that EPA treatment potentiates the integration of CREB dependent signaling with HLH/bHLH transcriptional network, adding specificity to the CREB1-mediated gene regulation during neural/glial differentiation. Our current research on the EPA-CREB axis could reveal new molecular targets for treating neurogenerative disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1860, Issue 8, August 2017, Pages 870-884
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1860, Issue 8, August 2017, Pages 870-884
نویسندگان
Maurizio Rossi, Martin Spichty, Lucilla Attorri, Chiara Distante, Clara Nervi, Serafina Salvati, Luigi Vitelli,