کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5508754 | 1400398 | 2017 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Contrasting effects of glutamine deprivation on apoptosis induced by conventionally used anticancer drugs
ترجمه فارسی عنوان
اثرات متضاد محرومیت گلوتامین در آپوپتوز ناشی از داروهای ضد سرطانی مورد استفاده قرار می گیرد
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کلمات کلیدی
DTNBDISCFADDBSOFLIPDR55,5′-dithiobis-(2-nitrobenzoic acid) - 5،5'-dithiobis- (2-nitrobenzoic acid)buthionine sulphoximine - بوته یونین سولفوکسیامینFas-associated protein with death domain - پروتئین مرتبط با Fas با دامنه مرگdeath-inducing signaling complex - پیچیدگی سیگنالینگ ناشی از مرگdeath receptor 5 - گیرنده مرگ 5
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Tumor cells dependence on glutamine offers a rationale for their elimination via targeting of glutamine metabolism. The aim of this work was to investigate how glutamine deprivation affects the cellular response to conventionally used anticancer drugs. To answer this question, neuroblastoma cells were pre-incubated in a glutamine-free medium and treated with cisplatin or etoposide. Obtained results revealed that glutamine withdrawal affected cellular response to therapeutic drugs in a different manner. Glutamine deprivation suppressed etoposide-induced, but markedly stimulated cisplatin-induced apoptosis. Suppression of etoposide-induced cell death correlated with a downregulation of p53 expression, which, among other functions, regulates the expression of death receptor 5, one of the activators of caspase-8. In contrast, stimulation of cisplatin-induced cell death involved reactive oxygen species-mediated downregulation of FLIP-S, an inhibitor of caspase-8. As a result, the activity of caspase-8 was stimulated causing cleavage of the pro-apoptotic protein Bid, which is involved in the permeabilization of the outer mitochondrial membrane and the release of pro-apoptotic factors, such as cytochrome c from mitochondria. Thus, suppression of glutamine metabolism can sensitize tumor cells to treatment and could be utilized for anti-cancer therapy. However, it should be done cautiously, since adverse effects may occur when combined with an inappropriate therapeutic drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1864, Issue 3, March 2017, Pages 498-506
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1864, Issue 3, March 2017, Pages 498-506
نویسندگان
Kadri Valter, Lian Chen, Björn Kruspig, Polina Maximchik, Hengmin Cui, Boris Zhivotovsky, Vladimir Gogvadze,