کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5509253 1538504 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewRecent development of signaling pathways inhibitors of melanogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
ReviewRecent development of signaling pathways inhibitors of melanogenesis
چکیده انگلیسی


- Melanin plays a monumental role in protecting the human skin.
- Signaling pathways inhibitors of melanogenesis.
- Tyrosinase is a key enzyme in melanin production.
- Autophagy mechanism regulates melanogenesis.

Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation. Melanogenesis, a biosynthetic pathway to produce melanin pigment in melanocyte, involves a series of intricate enzymatic and chemical catalyzed reactions. Several extrinsic factors include ultraviolet radiation and chemical drugs, and intrinsic factors include molecules secreted by surrounding keratinocytes or melanocytes, and fibroblasts, all of which regulate melanogenesis. This article reviews recent advances in the development of melanogenesis inhibitors that directly/indirectly target melanogenesis-related signaling pathways. Efforts have been made to provide a description of the mechanism of action of inhibitors on various melanogenesis signaling pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 40, December 2017, Pages 99-115
نویسندگان
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