کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5513737 1541269 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients
ترجمه فارسی عنوان
همبستگی بین پرفیوژن خون و ضخامت پوست در مناطق مختلف پوست بیماران اسکلروز سیستمیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- Imaging is an important adjunct to quantify and follow some aspects of SSc.
- Both LASCA and skin high frequency ultrasound are safe and not invasive techniques.
- Both LASCA and skin high frequency ultrasound allow to follow-up several aspects of the disease course in SSc patients.
- LASCA and US together may give the possibility to quantify in SSc the therapeutic effects of different regimens.

ObjectiveTo identify possible correlations between skin blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients.MethodsSixty-two SSc patients, according to 2013 EULAR/ACR criteria, and 62 healthy subjects (CNT) were enrolled. Skin BP was analysed by laser speckle contrast analysis (LASCA) at the level of dorsum of the middle phalanx of the third fingers, dorsal aspect of the hands and zygoma. DT was assessed by both skin high frequency ultrasound (US) and modified Rodnan skin score (mRSS) in the same above reported areas. All patients were studied also by nailfold videocapillaroscopy (NVC) to assess the proper pattern of microvascular damage (“Early”, “Active”, or “Late”).ResultsAt the level of finger dorsum a statistically significant negative correlation was observed in SSc patients between skin BP and both ultrasound-DT (p = 0.0005 r = 0.43) and mRSS (p = 0.0007 r = 0.42), but not at the level of hand dorsum and zygoma. No statistically significant correlation was present between skin BP and ultrasound-DT at any level in CNT. In detail, SSc patients, compared to CNT, showed a statistically significant lower BP only at level of fingers (median PU 72.6 vs 136.1 respectively, p < 0.0001) and a statistically significant higher ultrasound-DT at the level of dorsum of 3th finger bilaterally (median mm 0.9 vs 0.7, p < 0.0001), dorsum of hands (median mm 0.9 vs 0.7, p < 0.0001) and zygoma (median mm 0.8 vs 0.7, p < 0.0001). A significant positive correlation between ultrasound-DT and mRSS was observed in SSc patients at level of the three areas (dorsum of fingers p < 0.0001 r = 0.51; dorsum of hands p = 0.03 r = 0.27; zygoma p = 0.0001 r = 0.45). A progressive decrease of skin BP and increase of ultrasound-DT was found correlated with the progression of the severity of NVC patterns.ConclusionsThis study demonstrates for the first time in SSc patients a significant inverse relationship between skin BP, measured by LASCA, and DT, evaluated by both US and mRSS, at the level of dorsum of the middle phalanx of the third fingers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 115, January 2018, Pages 28-33
نویسندگان
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