کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5514969 1541806 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleContribution of dopaminergic and noradrenergic systems in the antinociceptive effect of α-(phenylalanyl) acetophenone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Original articleContribution of dopaminergic and noradrenergic systems in the antinociceptive effect of α-(phenylalanyl) acetophenone
چکیده انگلیسی

BackgroundThis study evaluated the antinociceptive action of α-(phenylalanyl) acetophenone (PSAP) in mice.MethodsEvaluated whether the serotonergic, adrenergic and dopaminergic systems are involved in PSAP antinociceptive activity. PSAP was administered intragastrically (ig) 30 min prior to formalin or glutamate test and compared with a standard drug, meloxicam (10 mg/kg, ig).ResultsThe treatment with PSAP (10-50 mg/kg) caused inhibition in the neurogenic phase and reduced the paw oedema caused by intraplantar (ipl) injection of formalin. PSAP (1-50 mg/kg) decreased the nociceptive response in the inflammatory phase of the formalin test and in licking behaviour triggered by glutamate at doses of 0.1-50 mg/kg. The antinociceptive effect of PSAP (1 mg/kg) was abolished when the animals were pre-treated with prazosin (α1-adrenergic antagonist receptor, 0.15 mg/kg, intraperitoneally [ip]), yohimbine (α2-adrenergic antagonist receptor, 1 mg/kg, ip) and sulpiride (D2/D3 dopamine antagonist, 5 mg/kg, ip). The antinociceptive effect of PSAP (1 mg/kg) was not abolished by WAY100635 (5-HT1A-selective serotoninergic antagonist, 0.7 mg/kg, ip), ketanserin (selective antagonist of serotonergic 5-HT2A/2C, 0.3 mg/kg, ip), ondansetron (5-HT3 selective serotoninergic antagonist, 0.5 mg/kg, ip) or SCH23390 (D1 dopamine receptor antagonist, 0.05 mg/kg, ip) in the glutamate test. No changes in locomotor activity were observed in the animals treated with PSAP and/or antagonists in the open field test.ConclusionThese results showed the antinociceptive action of PSAP in formalin and glutamate tests and the involvement of the dopaminergic and adrenergic systems in its antinociceptive activity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 5, October 2017, Pages 871-877
نویسندگان
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