کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515037 1400744 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original article2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation
ترجمه فارسی عنوان
مقاله اصلی 2-فتالیمیداتانول و 2-فتالیدیدیل نیتروتین، آلدینیائی مکانیکی، استخراج نوتروفیل ها و تولید سیتوکین و تولید کموکین در یک مدل موی التهابی مفصلی را مهار می کند.
کلمات کلیدی
آنالوگهای فتالیمید، 2-فتالیمیداتانول، 2-فتالیدیدیل نیترات، التهاب درد،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundPhthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation.MethodsArticular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice. The animals were pre-treated with PTD-OH or PTD-NO (500 mg/kg, per os, - 1 h). Nociceptive threshold was measured using an electronic von Frey apparatus. The total number of leukocytes in the synovial cavity was determined. Concentrations of tumor necrosis factor (TNF)-α and CXCL-1 and myeloperoxidase (MPO) activity were determined in periarticular tissue.ResultsBoth PTD-OH and PTD-NO inhibited at similar extent the mechanical allodynia, neutrophil recruitment to the synovial cavity and periarticular tissue and TNF-α and CXCL-1 production induced by intra-articular challenge with mBSA in immunized mice.ConclusionsPTD-OH and PTD-NO exhibit a marked activity in a murine model of antigen-induced articular inflammation in immunized animals. These results reinforce the interest in the investigation of phthalimide analogs devoid of the glutarimide ring as candidates to analgesic and anti-inflammatory drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 4, August 2017, Pages 691-695
نویسندگان
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