کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515060 1400746 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleEvaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease
ترجمه فارسی عنوان
مقاله اصلی بررسی اثر ضد التهابی دانه های شیشه ای با پوشش نقره ای در موش های مبتلا به کولیت ناشی از آزمایش به عنوان نوع جدید درمان در بیماری التهابی روده
کلمات کلیدی
بیماری کرون، بیماری روده التهابی میکروبیوتا، دانه های شیشه ای با نقره ای، کولیت زخم،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundRecent studies point at the anti-inflammatory action of silver through induction of apoptosis of inflammatory cells via oxidative stress, promotion of wound healing as well as antimicrobial effect. Our aim was to design a new formulation based on silver and validate its anti-inflammatory activity in the mouse models of colitis.MethodsSilver-coated glass beads were prepared using a magnetron sputtering method and a standard magnetron sputtering gun equipped with pure silver target. Colitis was induced by the ic administration of TNBS into colon (to mimic Crohn's disease) and addition of DSS to drinking water (to imitate ulcerative colitis). Evaluation of inflammation was performed based on macroscopic and microscopic scoring, quantification of the myeloperoxidase activity and colonic microflora analysis.ResultsSilver-coated glass beads administered ic alleviated intestinal inflammation in mouse models of colitis, induced by TNBS and DSS. This alleviation of colitis resulted principally from changes in the gut microflora. The anti-inflammatory action of the new formulation was associated predominantly with the presence of the silver nanolayer on the beads, and to a lesser extent the size of glass polymer units.ConclusionsThe application of the newly developed formulation employing silver-coated glass beads has the potential to be translated to clinical conditions for the efficient treatment of IBD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 3, June 2017, Pages 386-392
نویسندگان
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