Allimacrosides A-E, new steroidal glycosides from Allium macrostemon Bunge

- Nine steroidal compounds including five new compounds were isolated from Allium macrostemon.
- Their chemical structures were determined based on spectroscopic methods.
- The isolateds were tested for cytotoxicity against four human tumor cell lines in vitro.

A new pregnane-type steroidal glycoside (1), two new spirostane-type steroidal glycosides (2, 3), and two new furostane-type steroidal glycosides (4, 5), named allimacrosides A-E, together with four known compounds (6-9) were isolated from a 80% MeOH extract of Allium macrostemon Bunge. The identification and structural elucidation of these compounds were based on their 1D- and 2D-NMR spectra, and HR-FAB-MS data analysis. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.

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