کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5518408 1543953 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An adaptation of particle swarm clustering applied in basal cell carcinoma, squamous cell carcinoma of the skin and actinic keratosis
ترجمه فارسی عنوان
انطباق خوشه بندی ذره ای اعمال شده در کارسینوم سلول پایه، کارسینوم سلول سنگفرشی پوست و کراتوز فعال
کلمات کلیدی
پرورش خوشه ذرات، سرطان پوست، ضایعات بدخیم بالقوه، متاستاز، بیوانفورماتیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

IntroductionThis study used the comparison of basal cell carcinoma (BCC), squamous cell carcinoma of the skin (SCC) and actinic keratosis (AK) to test a new method for data set clustering in the leader gene approach.MethodsGenes related to BCC, SCC and AK, were identified in the databases: OMIM, Genecards and NCBI Gene. A network was built for BCC, SCC and AK using STRING. For each gene, a weighted number of links (WNL) was calculated based on the combined STRING scores. The genes were then clustered according to their WNL and TIS, using an adaptation of particle swarm clustering (PSC) or K-means clustering.ResultsA disagreement between K-means clustering and PSC was observed for both BCC and SCC. PSC suggested completed different leader genes to BCC and SCC. While K-means clustering indicated that CTNNB1 and TP53 were associated with BCC and SCC. In contrast, no differences in methods were observed to AK, which had the shorter network. TP53 was the only leader gene for AK.ConclusionIn conclusion, the current study suggests that PSC is an interesting tool for clustering genes in bioinformatics analyses of prevalent diseases. K-means clustering should be used in the small network. The current study also suggests TP53 may play a central role for AK. Additionally, CTNNB1 seems to be related to BCC, while CTNNA1 is related to SCC

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Meta Gene - Volume 12, June 2017, Pages 72-77
نویسندگان
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