کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5519076 1401100 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleExogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Original articleExogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways
چکیده انگلیسی

Melatonin is involved in the regulation of blood pressure through the receptor dependent or independent route. However, the effect of melatonin on fetal blood pressure is unknown. This study investigated the effect of melatonin on blood pressure of the late-term ovine fetus in utero. Melatonin and/or antagonists were intravenously administered into the fetuses. Mean arterial pressure and heart rate were recorded. Fetal blood samples were analyzed for biochemical parameters and hormones, including cortisol, angiotensin I, angiotensin II, aldosterone, atrial natriuretic peptide, corticotrophin-releasing hormone, adrenocorticotropic hormone, and endothelin. Fetal blood pressure was decreased following administration of melatonin, whereas it was increased following administration of luzindole, but not prazosin. Plasma level of endothelin was decreased by melatonin, which was blocked by luzindole. Our study suggested that melatonin reduced fetal blood pressure via MT1/MT2 receptors and possibly involving release of endothelin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Biology - Volume 16, Issue 3, September 2016, Pages 212-217
نویسندگان
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