NoteComparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity

- Validation of imipenem and meropenem for MALDI-TOF MS detection of carbapenemases
- Imipenem achieved the best sensitivity and specificity scores for P. aeruginosa.
- Whereas, meropenem was more efficient against Enterobacteriaceae

A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.