کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5528959 | 1548822 | 2017 | 5 صفحه PDF | دانلود رایگان |
IntroductionThe α4β2* nicotinic acetylcholine receptor (nAChR) system is implicated in many neuropsychiatric pathologies. [18F]Nifene is a positron emission tomography (PET) ligand that has shown promise for in vivo imaging of the α4β2* nAChR system in preclinical models and humans. This work establishes the radiation burden associated with [18F]nifene PET scans in humans.MethodsFour human subjects (2M, 2F) underwent whole-body PET/CT scans to determine the human biodistribution of [18F]nifene. Source organs were identified and time-activity-curves (TACs) were extracted from the PET time-series. Dose estimates were calculated for each subject using OLINDA/EXM v1.1.Results[18F]Nifene was well tolerated by all subjects with no adverse events reported. The mean whole-body effective dose was 28.4 ± 3.8 mSv/MBq without bladder voiding, and 22.6 ± 1.9 mSv/MBq with hourly micturition. The urinary bladder radiation dose limited the maximum injected dose for a single scan to 278 MBq without urinary bladder voiding, and 519 MBq with hourly voiding.Conclusions[18F]Nifene is a safe PET radioligand for imaging the α4β2* nAChR system in humans.Advances in Knowledge and Implications for Patient CareThis works presents human internal dosimetry for [18F]nifene in humans for the first time. These results facilitate safe development of future [18F]nifene studies to image the α4β2* nAChR system in humans.
Journal: Nuclear Medicine and Biology - Volume 55, December 2017, Pages 7-11