کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5544857 1555223 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phenobarbital or potassium bromide as an add-on antiepileptic drug for the management of canine idiopathic epilepsy refractory to imepitoin
ترجمه فارسی عنوان
فنوباربیتال یا پتاسیم برمید به عنوان یک داروی ضد صرعی برای کنترل صرع ایدوپاتیک کانین مقاوم به ایدئپتین
کلمات کلیدی
افزودن دارو ضد صرع، سگ ایمپیتین، فنوباربیتال، پتاسیم برومید،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


- Twenty-seven dogs refractory to a maximum dose of imepitoin (30 mg/kg twice daily) were enrolled.
- Phenobarbital or potassium bromide add-on treatment decreased seizure frequency.
- Combination therapy was well tolerated.

Imepitoin has recently been approved in Europe for the management of dogs with idiopathic epilepsy. Currently, there is no evidence-based information available on the efficacy of antiepileptic drugs used as additions to the therapeutic regimen in dogs with idiopathic epilepsy that are not well controlled with imepitoin. The goal of this study was to evaluate the efficacy of phenobarbital or potassium bromide (KBr) as add-on antiepileptic drugs for controlling dogs refractory to a maximum dose of imepitoin (30 mg/kg twice daily). The study was performed as a prospective, randomised, controlled clinical trial. The efficacy of phenobarbital and KBr was evaluated by comparing monthly seizure frequency (MSF), monthly seizure day frequency (MSDF), the presence of cluster seizures during a retrospective 2-month period with a prospective follow-up of 6 months, and the overall responder rate.Twenty-seven dogs were included in the study, 14 dogs in the phenobarbital group and 13 dogs in the KBr group. Both median MSF and MSDF decreased in the phenobarbital group (both P = 0.001) and in the KBr group (P = 0.004 and P = 0.003, respectively). Overall, the number of dogs with cluster seizures decreased (P = 0.0005). The responder rate was 79% vs. 69% in the phenobarbital and KBr groups, respectively. We conclude that phenobarbital or KBr add-on treatment decreases median MSF and MSDF in epileptic dogs refractory to a maximum dose of imepitoin. Combination therapy was generally well tolerated and resulted in an improvement in seizure management in the majority of the dogs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 220, February 2017, Pages 51-54
نویسندگان
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