|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5549509||1402878||2017||4 صفحه PDF||سفارش دهید||دانلود کنید|
The phenolics-rich fraction of Khaya senegalensis A. Juss (Meliaceae) stem bark extract (pfks) has been previously reported to possess potent antitrypanosomal activity at 300Â mg/kg body weight (bw) but could not completely prevent disease-induced anemia and organ damage in addition to being slightly hepatotoxic at the same dose. Therefore, the effects of a combined administration of low dose pfks and vitamin C on the severity of Trypanosoma brucei brucei infection in rats were investigated. Daily oral administration of a combined treatment of pfks (100Â mg/kg bw) and vitamin C (100Â mg/kg bw) for seven days significantly (pÂ <Â 0.05) reduced the number of T. brucei brucei in the bloodstream compared to infected untreated control with an ED50 of 51.15Â mg/kg bw. Also, the trypanosome-induced pathological alterations such as anemia, hepatic and renal damages were significantly (pÂ <Â 0.05) prevented by the same dosage of the combined treatment. Thus, the results obtained suggest that the combined treatment of a low dose of pfks and vitamin C is therapeutically potent as antitrypanosomal regimen and could effectively ameliorate the trypanosome-induced anemia and organ damage.
Journal: Synergy - Volume 4, June 2017, Pages 19-22