کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549923 1557280 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-delivery strategies to overcome multidrug resistance in ovarian cancer
ترجمه فارسی عنوان
استراتژی های همکاری برای غلبه بر مقاومت چندین دارو در سرطان تخمدان
کلمات کلیدی
همکاری، پمپ خروج مواد مخدر، هدفگیری مواد مخدر، مقاومت چند داروئی، نانوذرات چند منظوره، سرطان تخمدان،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Cancer is one of the leading causes of death and equally strikes both genders. Among women, ovarian cancer is responsible for many deaths as it remains symptomless in the earlier stages and generally diagnosed in third stage. At this point it becomes difficult to carry out de-bulking surgery and treatment with different chemotherapeutic drugs has shown resistance, a phenomenon known as multidrug resistance (MDR). Different treatment choices are available for ovarian cancer; however, this article only focuses on various co-delivery strategies, where two different agents are encapsulated in a single carrier and act via different pathways to overcome cancer cell resistance. Ovarian cancer develops MDR via different pathways but majorly involving pump and the non-pump mechanisms in most cases. To overcome MDR it is imperative to strike malignant cells from various directions. Nanocarriers are known to strike the pump mechanism by avoiding the drug efflux pump located on cellular membrane. The efflux pump can also be blocked by blocking activity of ATP binding cassette (ABC) membrane transporters. To stop the non-pump mechanism one can use chemosensitizers, genes, apoptotic factor and others. Treatment of cancer cells could even more effective if the drug is combined with co-agents in a single carrier with targeting moiety. These co-agents along with nanocarriers, allow the drug to accumulate in high enough concentrations in ovarian cancer cells to kill them without affecting normal cells.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 533, Issue 1, 25 November 2017, Pages 111-124
نویسندگان
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