کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550607 1557296 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exosomes as novel bio-carriers for gene and drug delivery
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Exosomes as novel bio-carriers for gene and drug delivery
چکیده انگلیسی

Clinical treatments have stalled in certain diseases due to a lack of proper therapeutic delivery systems. Recent studies have identified exosomes for their potential use as cell-free therapies, which may provide a novel mechanism for solving this problem. Exosomes are nanoscale extracellular vesicles that can transport rich cargos of proteins, lipids, DNA, and RNA. It is increasingly recognized that exosomes play a complex role in not only the physiological conditions but also pathological ones. Accumulating evidence suggests that exosomes are of paramount importance in distant cell-cell communication because they can enter the circulation when secreted and pass through additional biological barriers. As a result, interest has exploded surrounding the functional parameters of exosomes and their potential applications as delivery vehicles for small molecule therapies. In this review, we discuss the potential of exosomes to be utilized as “natural nanoparticles” to deliver drugs and genes, and their advantages and disadvantages are compared to other delivery mechanisms.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 521, Issues 1–2, 15 April 2017, Pages 167-175
نویسندگان
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