کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5551819 1557803 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells
ترجمه فارسی عنوان
هپارین مانع از اثرات ویروس زیکا-سیتوپاتیک در سلول های پیشگیرانه عصبی انسان می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Recent outbreak of Zika virus in Brazil included widespread neurological effects.
- One approach to tackling emerging infection is to re-purpose existing pharmaceuticals.
- The anticoagulant, heparin, inhibits infection weakly, but completely prevents cell death.

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 140, April 2017, Pages 13-17
نویسندگان
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