کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5552942 | 1557951 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
β-Caryophyllene ameliorates the development of experimental autoimmune encephalomyelitis in C57BL/6 mice
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کلمات کلیدی
NF-κBCB2IFN-γConAβ-CaryophylleneEAEiNOSBCPConcanavalin ACFAcomplete Freund's adjuvant - adjuvant دوست کاملHydrogen peroxide - آب اکسیژنهexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیtumor necrosis factor-alpha - تومور نکروز عامل آلفاCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa B - فاکتور هسته ای کاپا BNatural products - فرآورده های طبیعیMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)nitrite oxide - نیتریت اکسیدnitric oxide synthase - نیتریک اکسید سنتازH2O2 - هیدروژن پراکسیدInterferon gamma - گاما اینترفرونcannabinoid receptor type 2 - گیرنده کانابینوئید نوع 2
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Multiple sclerosis is the most common autoimmune inflammatory and demyelinating disease of the central nervous system. The experimental autoimmune encephalomyelitis (EAE) is an appropriate and a well-establish model for studying the pathogenesis of MS. β-caryophyllene (BCP), a natural sesquiterpene found in many plant species, is a potent anti-inflammatory compound. Herein we investigated the in vitro and in vivo immunomodulatory effects of BCP on C57BL/6 mice induced with EAE. BCP was in vitro evaluated (4, 20, and 40 μM) on splenocytes obtained from EAE-induced C57BL/6 mice, and in vivo (25 or 50 mg/kg/day) orally administered on EAE-mice. The clinical course, body weight, cytokines and oxygen radicals production were investigated in C57BL/6 EAE-mice. In vitro and in vivo immunological responses were evaluated by ELISA, and CNS sections were stained by hematoxylin and eosin methods The in vitro production of H2O2, NO, IFN-γ, and TNF- α was inhibited by BCP (20 and 40 μM) in cultured cells from EAE-mice. BCP (25 and 50 mg/kg/day) reduced clinical score and severity of EAE and inhibited H2O2, NO, TNF-α, IFN-γ and, IL-17 production. EAE-mice, orally treated with BCP (mainly at 50 mg/kg/day), displayed levels of cytokines and clinical signs similar to animals with no EAE disease, demonstrating the therapeutic action of BCP on EAE animals. Histopathological and histomorphometric analysis confirmed that BCP treatment significantly reduced the numbers of inflammatory infiltrates and attenuated neurological damages in the CNS of EAE-mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 91, July 2017, Pages 257-264
Journal: Biomedicine & Pharmacotherapy - Volume 91, July 2017, Pages 257-264
نویسندگان
LÃvia B.A. Fontes, Débora dos S. Dias, Beatriz J.V. Aarestrup, Fernando M. Aarestrup, Ademar A. Da Silva Filho, José Otávio do Amaral Corrêa,