کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5553474 1557955 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary supplementation of grape seed and skin flour mitigates brain oxidative damage induced by a high-fat diet in rat: Gender dependency
ترجمه فارسی عنوان
مکملهای غذایی دانه آفتاب و پوست باعث کاهش آسیب اکسیداتیو مغزی ناشی از رژیم غذایی با چربی بالا در موش صحرایی: وابستگی جنسیتی
کلمات کلیدی
جنسیت، دانه انگور و آرد پوست، سمیت چربی مغزی استرس اکسیداتیو، محافظت از عصب
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
چکیده انگلیسی

It is unknown whether gender has an impact on brain injury in obesity, and, if so, whether treatment with grape seed and skin flour could exert a protective effect. Both male and female rats were fed a standard diet (SD) or a high fat diet (HFD) during eight weeks and treated with high dosage grape seed and skin flour (GSSF). Fat-induced oxidative stress was evaluated into the brain with a special emphasis on transition metals determination. HFD induced male-cholesterol overload (+78.12%) and an oxidative stress status characterized by increased lipoperoxidation (+68.97%), carbonylation (+40.28%), decreased antioxidant enzyme activities as glutathione peroxidase (−61.07%) and manganese-superoxide dismutase (−35.47%) but not catalase. Additionally HFD depleted the brain from manganese (−71.31%) and dropped glutamine synthetase activity (−36.16%), without affecting copper nor iron nor their associated enzymes. HFD also altered intracellular mediators as superoxide anion (+36.12%), calcium (+44.41%) and also calpain (+76.54%) a calcium dependent protease. Importantly all these alterations were detected exclusively in male brain and were efficiently corrected upon GSSF treatment. In conclusion, GSSF has the potential to alleviate the deleterious lipotoxic effect of HFD treatment that occurred in male brain and perhaps in post-menauposal female brain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 87, March 2017, Pages 519-526
نویسندگان
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