کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5554291 1558115 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of sex on cardiovascular drug responses: role of estrogen
ترجمه فارسی عنوان
تأثیر رابطه جنسی در پاسخهای داروهای قلبی عروقی: نقش استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- Oxidative stress transforms estrogen into a pro-inflammatory hormone.
- Estrogen receptor-alpha signaling enhances cardiac catalase and mtALDH2 activities.
- Kidney function influences therapeutic outcomes and toxicity in females.

In this review we discuss the sex/estrogen-specific modulation of cardiovascular function and responses to current therapeutics. We discuss how anatomical differences such as a smaller kidney size, and lower glomerular filtration rate in females, reduce the clearance and increase the toxicity of some drugs in females. Other important sex differences include the dampening effect of estrogen on central sympathetic and renin angiotensin systems. Further, we discuss how a shift in myocardial redox status leads to paradoxical transformation of estrogen into a pro-inflammatory hormone. Finally, the review, along with cited recent publications, identify some areas that need further investigation to advance our understanding of the sex differences in cardiovascular disease outcomes to help develop female specific interventions for these anomalies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 33, April 2017, Pages 1-5
نویسندگان
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