کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5555544 | 1559748 | 2017 | 8 صفحه PDF | دانلود رایگان |
- There were significant difference of ALT norm level between TDF and ETV in the short-term period.
- There was significant difference of undetectable HBV-DNA only in 3 months follow up period.
- There were significant difference between TDF and ETV in eGFR level and hypophosphatemia incidence.
BackgroundThe purpose of this study was to assess the efficacy and safety between tenofovir and entecavir in the treatment of CHB and HBV related cirrhosis through Meta-analysis. MethodsThe electronic databases of PubMed, the Cochrane Library, Nature, CNKI and WanFang data were searched. The key words were: (“tenofovir”, “entecavir”) and (“Chronic Hepatitis B” or “CHB”) and “Liver cirrhosis”. Heterogeneity and report bias were analyzed.ResultsThere was significant difference of ALT norm level in the short-term period of 3Â months (RRÂ =Â 1.43, 95%CI: 1.06-1.94, PÂ <Â 0.017) and 6Â months (RRÂ =Â 0.89, 95%CI: 0.81-0.97, PÂ <Â 0.017), and significant difference of undetectable HBV-DNA only in 3Â months follow-up period (RRÂ =Â 1.59, 95%CI: 1.04-2.42, PÂ <Â 0.017) between TDF and ETV, but no significant difference in the long-term period. There is significant difference between TDF and ETV in eGFR level (RRÂ =Â 1.601, 95%CI: 1.035-2.478, PÂ =Â 0.0034) and hypophosphatemia incidence (RRÂ =Â 4.008, 95%CI: 1.485-10.820, PÂ =Â 0.006).ConclusionTDF has a better efficacy than ETV in 3Â months treatment duration, but intriguingly, TDF might not better than ETV during the 6Â months treatment period in the viral suppression and liver function improvement. There's no significant difference between TDF and ETV in the long-term treatment duration and in the treatment of HBV related liver cirrhosis. Both TDF and ETV could influence renal function but patients under TDF therapy may have more risk to suffer from renal damage and hypophosphatemia.
Journal: International Immunopharmacology - Volume 42, January 2017, Pages 168-175