کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5557081 1560562 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of adenosine A2b receptor overexpression in tumor progression
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Role of adenosine A2b receptor overexpression in tumor progression
چکیده انگلیسی

The adenosine A2b receptor is a G-protein coupled receptor. Its activation occurs with high extracellular adenosine concentration, for example in inflammation or hypoxia. These conditions are generated in the tumor environment. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. Thus A2b participates in different events, such as angiogenesis and metastasis, besides exerting immunomodulatory effects that protect tumor cells. Therefore, adenosine A2b receptor appears as an interesting therapeutic target for cancer treatment.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 166, 1 December 2016, Pages 92-99
نویسندگان
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