کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558076 1403197 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bioactive lipids as new class of microglial modulators: When nutrition meets neuroimunology
ترجمه فارسی عنوان
لیپید های بیولوژیکی به عنوان کلاس جدیدی از مولکول های میکروگلالیال: هنگامی که تغذیه با مغز استخوان مطابقت دارد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی

Within the central nervous system the traditional role of microglia has been in brain infection and disease, phagocytosing debris and secreting factors to modify disease progression. More recently, microglia have been found to be important for normal brain development, circuit refinement, and synaptic plasticity in ways that were previously unsuspected. Hence, the brain innate immune system appears to be key in all situations, ranging from physiology to pathology. This unique feature of microglia is established by the wide array of receptors it is equipped with to sense molecular patterns. This includes receptors to most if not all neurotransmitters, neuromodulators and purines. We here review novel, yet extensive literature on a new class of microglia modulators, namely bioactive fatty acids. These lipids are issued from metabolism of nutrients and can cross the blood brain barrier to reach the CNS. They appear to be direct modulators of microglial activity, triggering/inhibiting inflammatory processes or enhancing/inhibiting the ability of these cells to respond to hazardous agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 79, Part A, 3 October 2017, Pages 19-26
نویسندگان
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