کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559037 1403264 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiac regenerative medicine: At the crossroad of microRNA function and biotechnology
ترجمه فارسی عنوان
پزشکی احیاکننده قلب: در تقاطع عملکرد میکروارگانیسم و ​​بیوتکنولوژی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی
There is an urgent need to develop new therapeutic strategies to stimulate cardiac repair after damage, such as myocardial infarction. Already for more than a century scientist are intrigued by studying the regenerative capacity of the heart. While moving away from the old classification of the heart as a post-mitotic organ, and being inspired by the stem cell research in other scientific fields, mainly three different strategies arose in order to develop regenerative medicine, namely; the use of cardiac stem cells, reprogramming of fibroblasts into cardiomyocytes or direct stimulation of endogenous cardiomyocyte proliferation. MicroRNAs, known to play a role in orchestrating cell fate processes such as proliferation, differentiation and reprogramming, gained a lot of attention in this context the latest years. Indeed, several research groups have independently demonstrated that microRNA-based therapy shows promising results to induce heart tissue regeneration and improve cardiac pump function after myocardial injury. Nowadays, a whole new biotechnology field has been unveiled to investigate the possibilities for efficient, safe and specific delivery of microRNAs towards the heart.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Non-coding RNA Research - Volume 2, Issue 1, March 2017, Pages 27-37
نویسندگان
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