کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559053 1403265 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of DNA repair by non-coding miRNAs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Regulation of DNA repair by non-coding miRNAs
چکیده انگلیسی

DNA repair is an important signaling mechanism that is necessary to maintain genomic stability. Various types of DNA repair proteins are involved in the repair of different types of DNA damage. However, most of the DNA repair proteins are modified post-translation in order to activate their repair function, such as, ubiquitination, phosphorylation, acetylation, etc. Similarly, DNA repair proteins are also regulated by posttranscriptional modifications. Non-coding microRNAs (miRNAs) induced posttranscriptional regulation of mRNAs has gained attention in recent years. MiRNA-induced regulation of DNA repair proteins is of great interest, owing to its potential role in cancer therapy. In this review, we have summarized the role of different miRNAs in the regulation of various types of DNA repair proteins, which are essential for the maintenance of genomic stability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Non-coding RNA Research - Volume 1, Issue 1, October 2016, Pages 64-68
نویسندگان
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