کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5559098 | 1403268 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Les résultats faux positifs ou quelle est la probabilité que le traitement soit efficace quand p < 0,05 ?
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
فارماکولوژی، سم شناسی و اقلام دارویی (عمومی)
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چکیده انگلیسی
The use of statistical test is central in the clinical trial. At the statistical level, obtaining a PÂ <Â 0.05 allows to claim the effectiveness of the new studied treatment. However, given its underlying mathematical logic the concept of “P value” is often misinterpreted. It is often assimilated, mistakenly, to the likelihood that treatment is ineffective. Actually the “P value” gives an indirect information about the plausibility of the existence of treatment effect. With “PÂ <Â 0.05”, the probability that the treatment is effective may vary depending on other statistical parameters which are the alpha level of risk, the power of the study and especially the a priori probability of the existence of treatment effect. A “PÂ <Â 0.05” does not always produce the same degree of certainty. Thus there exist situations where the risk of a result “PÂ <Â 0.05” is in reality a false positive is very high. This is the case if the power is low, if there is an inflation of the alpha risk or if the result is exploratory or chance discoveries. This possibility is important to take into consideration when interpreting the results of clinical trials in order to avoid pushing ahead significant results in appearance, but which are likely to be actually false positive results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thérapie - Volume 72, Issue 4, September 2017, Pages 421-426
Journal: Thérapie - Volume 72, Issue 4, September 2017, Pages 421-426
نویسندگان
Michel Cucherat, Silvy Laporte,