کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560581 1561872 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study
چکیده انگلیسی


- The association of POPs and prostate cancer incidence risk was evaluated.
- Serum levels of PCBs and OCPs were measured.
- Both linear and non-linear analyses were conducted.
- PCBs and TEQ were associated with the increased risk of prostate cancer.
- Total OCPs was not associated with the prostate cancer risk.

It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk.Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model.Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30-13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75-9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33-14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21-9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52-12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer.Our findings suggested a possible role of POPs in the etiology of prostate cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 220, Issue 5, July 2017, Pages 849-856
نویسندگان
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