The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations

- We highlight the need for the lowering of homocysteine in patients with Recurrent miscarriages.
- Supplementation with methylfolate, Vit B6 and B12 is effective for the lowering of hyperhomocysteinemia.
- Reduced homocysteine level prevents miscarriages.

In patients with MTHFR (methylenetetrahydrofolate reductase) mutations and hyperhomocysteinemia, recurrent pregnancy loss is a frequent feature. The aim of the study was to evaluate the impact of folic acid, vitamins B6 and B12 supplementation for the lowering of total homocysteine concentrations and pregnancy. 16 patients who had had 3 or more miscarriages and MTHFR mutations were used in the study. They received methylfolate (5 mg/day), vitamin B6 (50 mg/day) and vitamin B12 (1 mg/week). Supplementation induced a decrease in homocysteine from 19.4 ± 5.3 μmol/L to 6.9 ± 2.2 μmol/L after folate supplementation (p < 0.05). During one year 7 women became pregnant and delivered. Two women delivered from the homozygous C677T mutations group (7 patients) and combined heterozygous C677T/A1298C mutations group (5 patients), while 3 deliveries were in A1298C homozygous mutations group (4 patients). In conclusion, supraphysiologic methylfolate, vitamins B6 and B12 supplementation in woman with MTHFR mutations has a beneficial effect on pregnancy outcome.