کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5572175 | 1403848 | 2017 | 7 صفحه PDF | دانلود رایگان |
SummaryBackground & aimsSerum vitamin D concentration is reduced in patients with non-alcoholic fatty liver disease (NAFLD). Although the mechanism of vitamin D deficiency in liver disease is not fully understood, a few reports have suggested the beneficial effects of vitamin D supplements. The present study investigated changes in serum 25-hydroxy vitamin D level and clinical parameters after total calorie restriction with vitamin D intake reduction in NAFLD patients.MethodsNewly diagnosed NAFLD patients with elevated aminotransferase levels were chosen for a calorie restriction and weight-reduction program. A total of 82 patients received nutritional education from nutritionists every 2 weeks for 2 months. Serum 25-hydroxy vitamin D level, amount of vitamin D intake, and physical activity were thoroughly investigated.ResultsThe mean serum 25-hydroxy vitamin D concentration was 13.0Â ng/ml. Twenty-nine patients (35.4%) had severe vitamin D deficiency. Patients with a 25-hydroxy vitamin D concentration <10Â ng/ml had an increased risk of abdominal obesity (72.4% vs. 47.2%, PÂ =Â 0.023) and a higher prevalence of metabolic syndrome (69% vs. 42.2%, PÂ =Â 0.015) compared with patients with 25-hydroxy vitamin D levels >10Â ng/ml. Although total energy and vitamin D intake were reduced during the program, serum 25-hydroxy vitamin D levels increased in patients with NAFLD (PÂ <Â 0.001). Liver enzymes and metabolic parameters also improved, even as vitamin D intake decreased. Serum vitamin D concentration increased with body weight and intrahepatic fat reduction, independent of decreases in vitamin D intake.ConclusionsWeight loss per increased serum vitamin D level without vitamin D supplementation and improved metabolic parameters in NAFLD.
Journal: Clinical Nutrition - Volume 36, Issue 1, February 2017, Pages 191-197