کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5574489 | 1403936 | 2016 | 9 صفحه PDF | دانلود رایگان |
PurposeTo understand whether the use of antiplatelet agents leads to less intra-aneurismal tissue formation following coil implantation in a rat end-pouch external carotid artery (ECA) aneurysm model.MethodsEnd-pouch ECA aneurysms were created in adult rats and were then embedded with either platinum or HydroCoils. Rats were treated either with aspirin, clopidogrel, aspirinâ+âclopidogrel, or saline for 2 weeks after coil implantation. At 2 weeks after coil implantation, rats were sacrificed and the aneurysm pouch was removed for histological and immunohistochemical analysis. A blinded single observer calculated the percentage of the organized area and the residual length of elastic lamina within the aneurysm. Student's t-test was used to compare data from image analysis between the different groups.ResultsWithin the platinum group, the organized tissue area was not affected by antiplatelet administration (aspirin versus saline, Pâ=â.83; clopidogrel versus saline, Pâ=â.46; aspirinâ+âclopidogrel versus saline, Pâ=â.54). For the HydroCoil group, the organized tissue area was significantly reduced (aspirin versus saline, Pâ=â.02; clopidogrel versus saline, Pâ=â.04; aspirinâ+âclopidogrel versus saline, Pâ=â.02) in rats treated with antiplatelet agents; however, no difference (aspirin versus clopidogrel, Pâ=â.8; aspirin versus aspirinâ+âclopidogrel, Pâ=â.3; clopidogrel versus aspirinâ+âclopidogrel, Pâ=â.5) was found among type or combination of antiplatelets administered. HydroCoil-treated aneurysms had a similar number of macrophages compared to the platinum group (Pâ=â.3819); however, the HydroCoil group had significant suppression of macrophages in the groups treated with combined antiplatelets (Pâ=â.02).ConclusionFollowing HydroCoil implantation, the area of organized tissue is diminished significantly in a rat end-pouch ECA aneurysm model treated with antiplatelets.
Journal: Journal of Stroke and Cerebrovascular Diseases - Volume 25, Issue 11, November 2016, Pages 2610-2618