کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5577912 1566701 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ReportPsychological Characteristics and Pain Frequency Are Associated With Experimental Pain Sensitivity in Pediatric Patients With Sickle Cell Disease
ترجمه فارسی عنوان
ویژگی های توصیفی و ویژگی های شخصیتی و فراوانی درد در ارتباط با حساسیت درد در بیماران کودکان مبتلا به بیماری سل
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Pain sensitivity in sickle cell disease (SCD) is influenced by psychological factors.
- Frequency of pain episodes also influences pain sensitivity in SCD.
- Age- and gender-based normative data on pain sensitivity should be used to define impaired pain sensitivity in SCD.

Sickle cell disease (SCD) is associated with episodes of severe vaso-occlusive pain beginning in infancy with a subset of patients with SCD transitioning to chronic pain. Response to experimental pain using quantitative sensory testing in these patients suggests altered pain processing. The objectives of this study were to characterize sensitivity to multiple modalities of experimental pain stimuli and to interrogate the relationship of psychological covariates, clinical pain burden, and pain-related outcomes to experimental pain sensitivity in children with SCD compared with healthy individuals of similar age and sex. Cross-sectional assessments of psychological characteristics were performed, and quantitative sensory testing methods were used to measure experimental pain sensitivity in children age 8 to 21 years. Anxiety, depressive symptoms, catastrophizing, and somatization were found to be associated with increased sensitivity to experimental pain stimuli. Increased frequency of painful episodes in SCD was associated with decreased sensitivity to heat pain and decreased mechanical temporal summation. These data suggest that careful consideration be given to psychological factors, age, sex, and clinical burden of pain when studying response to experimental pain in SCD.PerspectiveIn this study of patients with SCD, a condition associated with recurrent acute or chronic pain, psychological factors such as depression, anxiety, and catastrophizing are associated with increased sensitivity to experimental pain stimuli. Further study is need to delineate the role of these factors in chronic SCD pain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pain - Volume 18, Issue 10, October 2017, Pages 1216-1228
نویسندگان
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