کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5587205 | 1568782 | 2017 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Renal glucose metabolism in normal physiological conditions and in diabetes
ترجمه فارسی عنوان
متابولیسم کلیه گلوکز در شرایط فیزیولوژیکی طبیعی و در دیابت
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کلمات کلیدی
FFASGLTGLUTT2DMT1DMSGLT2SGLT2isodium-glucose co-transporter 2Free fatty acids - اسیدهای چرب آِزادGlucose transporter - حمل و نقل گلوکزglucose transporters - حمل و نقل گلوکزDiabetes mellitus - دیابت قندیtype 1 diabetes mellitus - دیابت نوع 1Type 2 diabetes mellitus - دیابت نوع دوGlucose metabolism - متابولیسم گلوکزGlucose homeostasis - هوموستاز گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
The kidney plays an important role in glucose homeostasis via gluconeogenesis, glucose utilization, and glucose reabsorption from the renal glomerular filtrate. After an overnight fast, 20-25% of glucose released into the circulation originates from the kidneys through gluconeogenesis. In this post-absorptive state, the kidneys utilize about 10% of all glucose utilized by the body. After glucose ingestion, renal gluconeogenesis increases and accounts for approximately 60% of endogenous glucose release in the postprandial period. Each day, the kidneys filter approximately 180Â g of glucose and virtually all of this is reabsorbed into the circulation. Hormones (most importantly insulin and catecholamines), substrates, enzymes, and glucose transporters are some of the various factors influencing the kidney's role. Patients with type 2 diabetes have an increased renal glucose uptake and release in the fasting and the post-prandial states. Additionally, glucosuria in these patients does not occur at plasma glucose levels that would normally produce glucosuria in healthy individuals. The major abnormality of renal glucose metabolism in type 1 diabetes appears to be impaired renal glucose release during hypoglycemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 133, November 2017, Pages 1-9
Journal: Diabetes Research and Clinical Practice - Volume 133, November 2017, Pages 1-9
نویسندگان
Mazen Alsahli, John E. Gerich,