کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5593657 | 1571140 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Central and peripheral administrations of insulin-like growth factor-1 suppress food intake in chicks
ترجمه فارسی عنوان
تزریقات مرکزی و محیطی فاکتور رشد مانند انسولین-1 باعث کاهش مصرف غذا در جوجه ها می شود
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کلمات کلیدی
اشتها مغز، مرغ، مصرف خوراک، فاکتور رشد مانند انسولین-1، کبد،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
A number of studies have been made on the physiological actions of insulin-like growth factor-1 (IGF-1) in mammals and birds. In mammals, the effects of central administration of IGF-1 on food intake have been examined. For example, intracerebroventricular administration of IGF-1 significantly decreased food intake in diabetic rats, but not in sheep and nondiabetic rats. The chicken is known to be a hyperglycemic animal. Like satiety hormones, plasma IGF-1 levels are elevated postprandially in chickens. In this study, we hypothesized that IGF-1 is involved in the regulation of food intake in chickens. Intracerebroventricular administration of IGF-1 significantly suppressed food intake in chicks in a dose dependent manner. Both the mRNAs of IGF-1 and its receptor were expressed throughout the brain. However, the mRNA levels of IGF-1 were not influenced by fasting and refeeding in all regions of the brain. On the other hand, 6Â h of fasting significantly suppressed mRNA expression of hepatic IGF-1, and this effect was significantly reversed by 6Â h of refeeding. Furthermore, intravascular administration of IGF-1 significantly suppressed food intake in chicks. These findings suggest that IGF-1 may function as a satiety hormone in chickens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 179, 1 October 2017, Pages 308-312
Journal: Physiology & Behavior - Volume 179, 1 October 2017, Pages 308-312
نویسندگان
Shoichi Fujita, Kazuhisa Honda, Daichi Hiramoto, Mei Gyu, Mika Okuda, Shungo Nakayama, Mika Yamaguchi, Takaoki Saneyasu, Hiroshi Kamisoyama,