The increase in the rate of maternal deaths related to cardiovascular disease in Japan from 1991-1992 to 2010-2012

The present study demonstrates that the rate of MD-CVD among the cases of MD has increased 3-fold in Japan over the past 20 years. Thus, it is of critical importance to better understand the etiologies and early signs of MD-CVD and to devise an effective management program for pregnancies complicated by CVD.