کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5619469 | 1406071 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of hydroxychloroquine on endothelial dysfunction
ترجمه فارسی عنوان
اثرات هیدروکسی کلروکین بر اختلال اندوتلیال
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health - Volume 6, Issue 4, October 2016, Pages 259-262
Journal: Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health - Volume 6, Issue 4, October 2016, Pages 259-262
نویسندگان
Rahana Rahman, Padma Murthi, Harmeet Singh, Seshini Gurusinghe, Joanne C. Mockler, Rebecca Lim, Euan M. Wallace,