کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5621825 1579193 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full Length ArticlePlatelet-to-lymphocyte ratio as a novel marker of in-hospital and long-term adverse outcomes among patients with acute pulmonary embolism: A single center large-scale study
ترجمه فارسی عنوان
نسبت طول کامل ماده پلاکت به لنفوسیت به عنوان یک نشانگر جدید در بیماران مبتلا به آمبولی ریوی حاد و درازمدت در معرض خطر: یک مطالعه در مقیاس بزرگ یک مرکز
کلمات کلیدی
آمبولی ریه نسبت پلاکت به لنفوسیت، پیش بینی،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Hıghlıghts
- We assess the prognostic role of PLR in acute pulmonary embolism.
- In-hospital adverse events occurred more frequently in the highest tertile of PLR.
- Long-term all-cause mortality occurred more frequently in the third PLR tertile.
- PLR is significantly correlated with RV/LV ratio, cTnI levels and CTPAOI.
- PLR is a predictor of in-hospital adverse events and long-term all-cause mortality.

BackgroundThe interaction of platelets with leukocytes is a well-known process both in progression and prognosis of acute pulmonary embolism (PE). Recently, platelet to lymphocyte ratio (PLR) is emerged as an indirect inflammatory indicator which was shown to be associated with adverse cardiovascular events in various clinical conditions, including acute PE. However, the long-term prognostic value of PLR in acute PE has not been investigated thoroughly. Therefore, we aimed to assess the impact of PLR on both in-hospital and long-term adverse outcomes in acute PE.MethodsA total of 459 patients with definite diagnosis of acute PE between January 2009 and January 2016 were enrolled. On admission, blood sampling to calculate PLR and detailed clinical data were obtained. Patients were divided into tertiles according to the admission PLR levels. Simplified PE severity index (sPESI) score and computerized tomography (CT) based pulmonary artery obstruction index were calculated for each patient.ResultsMean sPESI score of the study population was 1.6. A total of 34 patients (7.4%) died during index hospitalization. At median 28.8 months follow-up, all-cause mortality was observed in 81 patients (1.9%). Patients in the highest tertile of PLR revealed a higher rate of in-hospital adverse events including cardiogenic shock, the necessity for thrombolytic therapy and in-hospital mortality as well as long-term all-cause mortality. In multivariate analysis, the PLR was found to be a significant predictor of both in-hospital adverse events (OR: 1.588, 95% CI:1.116-2.154, p = 0.004) and long-term all-cause mortality (OR:1.746, 95% CI:1.211-2.865, p = 0.001).ConclusionsThe PLR, as a simple, inexpensive and available marker of inflammatory and prothrombotic status, seemed to be a novel predictor of in-hospital and long-term adverse outcomes in patients with acute PE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 150, February 2017, Pages 33-40
نویسندگان
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