کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622169 1579191 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full Length ArticleReversal of dabigatran-associated major bleeding with activated prothrombin concentrate: A prospective cohort study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Full Length ArticleReversal of dabigatran-associated major bleeding with activated prothrombin concentrate: A prospective cohort study
چکیده انگلیسی


- An antidote for dabigatran reversal was recently approved.
- If the antidote is unavailable we propose activated prothrombin complex concentrate.
- aPCC had Good or Moderate effectiveness in 14 of 14 cases with major bleeds.
- No thromboembolic events occurred within 30 days.

The reversal of dabigatran-associated major bleeding can now be achieved with the antidote idarucizumab. We evaluated activated prothrombin complex concentrate (aPCC) as an alternative for this purpose.Patients treated with dabigatran and suffering a major bleed were treated as per existing hospital protocol with aPCC. They were subsequently recruited for a 30-day follow-up. Effectiveness was evaluated by the treating physician, using an Assessment Guide. Safety outcomes were arterial or venous thromboembolism or death. A comparison was also made with historic cases with dabigatran-associated major bleeds treated with supportive care, by matching 1:2 for type of bleed, age and sex.We aimed at 32 evaluable cases but the study was prematurely discontinued after 14 cases due to the availability of the approved antidote. The effectiveness of aPCC was assessed as Good in 9 (64%), moderate in 5 (36%) and poor in none. There were no thromboembolic events and one death. In the secondary adjudication of effectiveness, using the same criteria and by the same adjudicators as previously done for the historic cases, the outcome was graded for the current cases versus the historic cases as Good, Moderate, or Poor in 10 (71%) versus 16 (57%), 3 (21%) versus 4 (14%), and 1 (7%) versus 8 (29%), respectively.Although supportive care is sufficient to manage many patients with dabigatran-associated bleeding, aPCC might provide an additional benefit to control life-threatening bleeding in selected cases and does not appear to cause an excess of thromboembolic events.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 152, April 2017, Pages 44-48
نویسندگان
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