کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622769 1579254 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleThe midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleThe midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study
چکیده انگلیسی

IntroductionAlthough biomarker studies of late-onset Alzheimer's disease suggest pathology to be present decades before diagnosis, little is known about cognitive performance at this stage.MethodsA sample of 210 adults (aged 40-59) of whom 103 have a parent diagnosed with dementia (family history subgroup) underwent computerized cognitive testing. Apolipoprotein E (apoE) status was determined, and 193 subjects had magnetic resonance imaging. Distance from dementia onset was estimated in relation to age of parental diagnosis, and Cardiovascular Risk Factors, Aging, and Incidence of Dementia Risk Scores were calculated.ResultsLower hippocampal volumes (P = .04) were associated with poorer spatial location recall and higher Dementia Risk Scores with poorer visual recognition (P = .0005), and lower brain and hippocampal volume (P < .0001, P = .04, respectively). Family history subgroup participants closer to dementia onset had lower scores on visual working memory (P = .05), whereas those with an APOE ε4 allele performed better on form perception (P = .005).DiscussionMiddle-aged adults at risk of dementia show evidence of poorer cognitive performance, principally in visuospatial functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 10, October 2017, Pages 1089-1097
نویسندگان
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