|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5626596||1406325||2017||5 صفحه PDF||سفارش دهید||دانلود کنید|
BackgroundBioelectric field models of deep brain stimulation (DBS) are commonly utilized in research and industrial applications. However, the wide range of different representations used for the human head in these models may be responsible for substantial variance in the stimulation predictions.ObjectiveDetermine the relative error of ignoring cerebral vasculature and soft-tissue heterogeneity outside of the brain in computational models of DBS.MethodsWe used a detailed atlas of the human head, coupled to magnetic resonance imaging data, to construct a range of subthalamic DBS volume conductor models. We incrementally simplified the most detailed base model and quantified changes in the stimulation thresholds for direct activation of corticofugal axons.ResultsIgnoring cerebral vasculature altered predictions of stimulation thresholds by <10%, whereas ignoring soft-tissue heterogeneity outside of the brain altered predictions between â44 % and 174%.ConclusionsHeterogeneity in the soft tissues of the head, if unaccounted for, introduces a degree of uncertainty in predicting electrical stimulation of neural elements that is not negligible and thereby warrants consideration in future modeling studies.
Journal: Brain Stimulation - Volume 10, Issue 1, JanuaryâFebruary 2017, Pages 46-50