کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5626596 1406325 2017 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Role of Soft-Tissue Heterogeneity in Computational Models of Deep Brain Stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Role of Soft-Tissue Heterogeneity in Computational Models of Deep Brain Stimulation
چکیده انگلیسی

BackgroundBioelectric field models of deep brain stimulation (DBS) are commonly utilized in research and industrial applications. However, the wide range of different representations used for the human head in these models may be responsible for substantial variance in the stimulation predictions.ObjectiveDetermine the relative error of ignoring cerebral vasculature and soft-tissue heterogeneity outside of the brain in computational models of DBS.MethodsWe used a detailed atlas of the human head, coupled to magnetic resonance imaging data, to construct a range of subthalamic DBS volume conductor models. We incrementally simplified the most detailed base model and quantified changes in the stimulation thresholds for direct activation of corticofugal axons.ResultsIgnoring cerebral vasculature altered predictions of stimulation thresholds by <10%, whereas ignoring soft-tissue heterogeneity outside of the brain altered predictions between −44 % and 174%.ConclusionsHeterogeneity in the soft tissues of the head, if unaccounted for, introduces a degree of uncertainty in predicting electrical stimulation of neural elements that is not negligible and thereby warrants consideration in future modeling studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Stimulation - Volume 10, Issue 1, January–February 2017, Pages 46-50
نویسندگان
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