کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626982 1579661 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A randomized controlled study of intravenous fluid in acute ischemic stroke
ترجمه فارسی عنوان
یک مطالعه کنترل شده تصادفی از مایع داخل وریدی در سکته مغزی ایسکمیک حاد
کلمات کلیدی
سکته مغزی ایسکمیک، سکته مغزی سکته مغزی در تکامل، مایع داخل وریدی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Administration of normal saline for 72 h in patients with acute ischemic stroke is safe.
- Patients without intravenous fluid had significantly higher rate of early neurological deterioration.
- This study supports the use of intravenous fluid in acute ischemic stroke in patients who have no contraindications.

ObjectiveTo compare the outcome of patients with acute ischemic stroke who received or did not receive intravenous fluid.Patients and methodsThis study was a prospective, multicenter, randomized, open-label trial with blinded outcome assessment. We enrolled acute ischemic stroke patients without dehydration aged between 18 and 85 years with NIH Stroke Scale score (NIHSS) score from 1 to 18 who presented within 72 h after onset. Patients were randomly assigned to receive 0.9% NaCl solution 100 ml/h for 3 days or no intravenous fluid.ResultsOn the interim unblinded analysis of the safety data, significant excess early neurological deterioration was observed among patients in the non-intravenous fluid group. Therefore, the study was prematurely discontinued after enrollment of 120 patients, mean age 60 years, 56.6% male. Early neurological deterioration (increased NIHSS ≥3 over 72 h) not of metabolic or hemorrhagic origin was observed in 15% of the non-IV fluid group and 3.3% of the IV fluid group (p = 0.02). Predictors of neurological deterioration were higher NIHSS score, higher plasma glucose, and increased pulse rate. There was no difference in the primary efficacy outcome, NIHSS ≤ 4 at day 7, 83.3% vs 86.7%, p = 0.61 or secondary efficacy outcomes.ConclusionAdministration of 0.9% NaCl 100 ml/h for 72 h in patients with acute ischemic stroke is safe and may be associated with a reduced risk of neurological deterioration. These study findings support the use of intravenous fluid in acute ischemic stroke patients with NIHSS less than 18 who have no contraindications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 161, October 2017, Pages 98-103
نویسندگان
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