کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627598 1579720 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease
ترجمه فارسی عنوان
همبستگی بلند مدت فعالیت بتای ساب تالامام با اختلال حرکتی در بیماران مبتلا به بیماری پارکینسون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Subthalamic beta activity was recorded with an implantable DBS pulse generator over 8 months in 12 patients with Parkinson's disease.
- Dopaminergic medication suppresses subthalamic beta activity at operation, 3 and 8 months after DBS.
- Beta activity correlates with parkinsonian symptom severity over time.

ObjectivesTo investigate the long term association of subthalamic beta activity with parkinsonian motor signs.MethodsWe recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8 months post-operatively using the implantable sensing enabled Activa PC + S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13-35 Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores.ResultsPeaks in the beta frequency band (13-35 Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points (P < 0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ = 0.25, P < 0.001).ConclusionsOur results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8 months.SignificanceBeta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 11, November 2017, Pages 2286-2291
نویسندگان
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