کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5627650 1406352 2017 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
The generator site in acquired autoimmune neuromyotonia
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موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
The generator site in acquired autoimmune neuromyotonia
چکیده انگلیسی


- We applied a double-needle EMG recording to investigate the origin of spontaneous discharges in neuromyotonia.
- Intravenous immunoglobulin preferentially modulates spontaneous discharges proximal to distal axonal branches.
- Treatment effects can shed light on the origin of abnormal activity in neuromyotonia.

ObjectiveTo investigate the origin of ectopic activity in neuromyotonia (NMT).MethodsWe studied two patients. In addition to routine studies, we tested synchronicity of spontaneous discharges in different motor units in simultaneous recordings made with two needle electrodes in the first dorsal interosseus muscle. Time-locked fasciculations in these double recordings would represent abnormal ectopic activity initiated in a nerve trunk with ephaptic stimulation of a nearby axon. In patient 1, this research protocol was applied once, 15 years after regular intravenous immunoglobulin (IvIg) treatment. Patient 2 was investigated before and 1 year after IvIg.ResultsBoth patients improved after IVIg, mirrored by a striking decrease in the amount of spontaneous activity on electromyography. Moreover, our technique did not detect synchronous spontaneous activity (time-locked fasciculations) on the second assessment, although this was predominant before treatment in patient 2.ConclusionsIn NMT, abnormal discharges originate both in distal axonal branches and in more proximal segments. It appears that IvIg is more effective in blocking antibody activity in proximal axonal segments, perhaps related to factors such as blood-nerve barrier, temperature or differing ion channel distributions.SignificanceTreatment effects can shed light on the origin of abnormal activity in NMT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 4, April 2017, Pages 643-646
نویسندگان
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