کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627694 1406354 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
After-discharges and seizures during pediatric extra-operative electrical cortical stimulation functional brain mapping: Incidence, thresholds, and determinants
ترجمه فارسی عنوان
پس از تخلیه و تشنج در طویله مغزی کارکرد مغزی کارکردی کودکان: بروز، آستانه و عوامل تعیین کننده
کلمات کلیدی
نقشه برداری تحریک کورتکس، نقشه برداری مغزی کارکردی، جراحی صرع، آستانه فعلی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Electrical cortical stimulation shows high incidence of after-discharges (77%) and seizures (35%)
- Current thresholds for after-discharges show a significant linear decreasing trend with age.
- After-discharges predict 3.5 times higher odds of having a seizure during cortical stimulation.

ObjectiveThis study examined the incidence, thresholds, and determinants of electrical cortical stimulation (ECS)-induced after-discharges (ADs) and seizures.MethodsElectrocorticograph recordings were reviewed to determine incidence of ECS-induced ADs and seizures. Multivariable analyses for predictors of AD/seizure occurrence and their thresholds were performed.ResultsIn 122 patients, the incidence of ADs and seizures was 77% (94/122) and 35% (43/122) respectively. Males (odds ratio [OR] 2.92, 95% CI 1.21-7.38, p = 0.02) and MRI-negative patients (OR 3.69, 95% CI 1.24-13.7, p = 0.03) were found to have higher odds of ECS-induced ADs. A significant trend for decreasing AD thresholds with age was seen (regression co-efficient −0.151, 95% CI −0.267 to −0.035, p = 0.011). ECS-induced seizures were more likely in patients with lateralized functional imaging (OR 6.62, 95% CI 1.36-55.56, p = 0.036, for positron emission tomography) and presence of ADs (OR 3.50, 95% CI 1.12-13.36, p = 0.043).ConclusionsECS is associated with a high incidence of ADs and seizures. With age, current thresholds decrease and the probability for AD/seizure occurrence increases.SignificanceADs and seizures during ECS brain mapping are potentially hazardous and affect its functional validity. Thus, safer method(s) for brain mapping with improved neurophysiologic validity are desirable.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 10, October 2017, Pages 2078-2086
نویسندگان
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