کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627696 1406354 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Left hemispheric breakdown of LTP-like cortico-cortical plasticity in schizophrenic patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Left hemispheric breakdown of LTP-like cortico-cortical plasticity in schizophrenic patients
چکیده انگلیسی


- Schizophrenia is characterized by altered intra-hemispheric connectivity and cortical plasticity.
- We evaluated cortico-cortical associative plasticity of both hemispheres using cc-PAS protocol.
- Patients with schizophrenia showed weaker late LTP-like plasticity in left but not right hemisphere.

ObjectiveAltered cortical connectivity and plasticity seems to be asymmetrical between the hemispheres in patients with schizophrenia (SCZ). We evaluated long-term potentiation (LTP) in parietal-frontal circuits of both hemispheres using a cortico-cortical Paired Associative Stimulation (cc-PAS) protocol testing the rules of Hebbian-like spike timing dependent plasticity (SPTD).Methods12 SCZ and 12 healthy subjects (HS) underwent a cc-PAS protocol to activate, by means of paired pulses of transcranial magnetic stimulation (TMS), the short-latency connection between posterior parietal cortex (PPC) and primary motor cortex (M1) of both hemispheres. Motor-evoked potentials (MEPs) were collected to assess the time course of the after effects of cc-PAS protocol measuring MEP amplitude as index of cortico-cortical associative plasticity.ResultsWhile HS showed a similar time course of LTP-like plasticity in the two hemispheres, SCZ revealed a weaker late-LTP-like plasticity in the left compared to the right hemisphere after cc-PAS protocol.ConclusionsSCZ failed to show the typical long-lasting increase of M1 excitability observed after cc-PAS protocol in both hemispheres, with a greater reduction in the left one.SignificanceOur findings provide novel neurophysiological evidence for an asymmetric impairment of the left parietal-frontal network in SCZ patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 10, October 2017, Pages 2037-2042
نویسندگان
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